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The NTRK gene family encodes receptors that regulate multiple pathways crucial to nervous system development. NTRK fusions, which generate chimeric proteins with unchecked NTRK signaling, have emerged as disease drivers across a range of cancers.
Pediatric acute myeloid leukemia (AML) makes up approximately a quarter of childhood cancer cases. Cytogenetics studies have been instrumental in clarifying the mutational landscape of childhood AML, which has helped classify the disease into subtypes according to genetic drivers.
As the second most common cancer worldwide and the most common cause of cancer death in women, breast cancer remains an international health burden. Fortunately, progress continues to be made in unraveling the many factors that contribute to breast cancer development, including its unique genetic abnormalities.
Lung cancer is the leading cause of global cancer fatalities, and the worldwide death rate continues to rise. The disease is a genetically heterogeneous one; many complex genetic alterations have been found to drive lung cancer progression, and more continue to be discovered.
Although survival rates have improved dramatically in the past decade, melanoma is still the deadliest skin cancer worldwide. Early detection is crucial in this rapidly progressing disease, and understanding melanoma genetics has been essential to uncovering its development from beginning stages to metastasis.