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CCND1/IGH Split Fusion FISH Probe

Our CCND1/IGH split probe is designed to detect fusions between CCND1 and IGH. To account for the high degree of cross homology in the region containing IGH, part of the IGH portion has been removed. The probe comes labeled in orange and green, but can be customized to meet your needs.

Gene Background: CCND1-IGH fusion is generated by t(11;14)(q13.3;q32.3), which places CCND1 gene next to IGH, resulting in constitutive overexpression of CCND1. The fusion can be found in up to 95% of patients with mantle cell lymphomas (MCL), and is considered the genetic hallmark of this subtype of low-grade peripheral B-cell neoplasms. CCND1-IGH has also been identified in other lymphoproliferative disorders (LPDs), such as B-prolymphocytic leukemia (BLL), and, less frequently, in plasma cell myelomas and B-cell chronic lymphocytic leukemia (CLL).

Source: Bentz JS, et al. (2004) Cancer 102:124-31. 

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CCND1-IGH-Split-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CCND1-IGH-Split-20-GOGR 20 (40 μL) 200 μL
CCND1-IGH-Split-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CCND1

Gene Name: Cyclin D1

Chromosome: CHR11: 69455872-69469242

Locus: 11q13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

Invasive lobular carcinoma (ILC) is a type of breast cancer defined by functional loss of E-cadherin, which results in cellular adhesion defects. This study sought to further characterize ILC’s genetic profile via analysis of 196 tumors. Using in silico integrative analyses, a 194-gene set – named ‘LobSig’ by the team – was identified, made up of genes frequently mutated in the tumor samples. LobSig was tested against the Nottingham Prognostic Index, PAM50 risk-of-recurrence (Prosigna), OncotypeDx, and Genomic Grade Index (MapQuantDx) for a 10-year follow-up period, and outperformed them all. As part of genetic profiling, Empire Genomics’ FGFR1 And CCND1 FISH probes were used to detect amplification of the genes.