Gene Fusion FISH Probes
Fusions occur when two normally separated genes are joined, which can contribute to cancer development in a few different ways. The translocated gene may fuse to a promoter, ramping up expression of the gene. Fusions can also create a chimeric gene that produces a novel hybrid protein with oncogenic potential. Lastly, a fusion can lead to tumorigenesis when it results in the truncation of a tumor suppressor gene.
Fusion probes contain 2 colors, each designed to hybridize to its respective gene. While a normal cell will display the colors as separate signals, a cell that has the fusion will show the signals less than one signal width apart. Each kit contains 20 tests and normally ships within 1-3 weeks. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads. These products are for research use only (RUO) and are not for use in diagnostic procedures.