ERBB2/Con17 FISH Probe
Our ERBB2/Control 17 probe is designed to detect ERBB2 amplifications and deletions. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: ERBB2 is a member of the receptor tyrosine kinase family, a subset of receptor proteins that bind epidermal growth factor (EGF).1 ERBB2 doesn’t have a binding domain itself, but stabilizes the configurations of other receptor proteins, making it easier for EGF to latch on.1 ERBB2 is involved in a lengthy list of important signaling cascades, as EGF is a ubiquitous mitogenic factor that stimulates cell growth in many tissue types.2 ERBB2’s oncogenic effects first came to light in 1987, when it was found to play a major role in breast cancer metastasis.3 The gene remains primarily associated with breast cancer (20-30% of breast cancer patients have amplified ERBB2) but it’s now also considered an important oncogene in uterine, gastric, pancreatic, colorectal and endometrial cancer, among others.4,5
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ERBB2-CHR17-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
|ERBB2-CHR17-20-REGR||20 (40 μL)||200 μL|
|ERBB2-CHR17-20-GOGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|