ABL1 Break Apart FISH Probe Version B
Our ABL1 break apart Version B probe is designed to detect ABL1 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: The ABL1 protein regulates actin binding and remodeling, cell motility and adhesion, receptor endocytosis and autophagy. It also aids in checkpoint repair after moderate DNA damage, and apoptosis after serious damage. Best known for its fusion with BCR in chronic myeloid leukemia, which produces the well-known BCR-ABL1 fusion gene or Philadelphia Chromosome, ABL1 has also been shown to fuse with several other partner genes. These include ETV6 in ALL, MPN, and Ph-negative CML; RCSD1, SEPQ, and ZMIZ1 in B-cell ALL; and NUP214 and EML1 in T-cell ALL. All of these fusions result from the joining of the 5’ sequences of the partner gene with the 3’ sequences of ABL1. Although most ABL1 fusion genes are associated with a distinct leukemia subtype, both BCR-ABL1 and ETV6-ABL1 are found in several disease phenotypes. Some studies have suggested that these non-specific fusion occur in hematopoietic pluripotent or committed stem cells, leading to leukemia with diverse phenotypes.
Source: De Braekeleer E, et al. (2011) Euro jour haem 86.5: 361-371.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ABL1BA-vB-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|ABL1BA-vB-20-GRRE||20 (40 μL)||200 μL|
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Symbol: ABL1
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267-133763062
FISH Probe Protocols
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