As of October 30th, Empire is operating as an essential New York State business and has no production or shipping delays

Follicular Lymphoma FISH Probes

BCL6 alterations are among the most common genetic abnormalities in B-cell tumors, and can be found in 6-14% of FL. BCL6 is unique from other lymphoma oncogenes in that it participates in fusions not just with IG genes, but other non-IG partners (so far, 20 different fusion partners have been reported).

BCL2/IGH fusion is found in nearly 90% of FL patients, occurring in the bone marrow during VDJ recombination at the pre B cell stage. The alteration is typically the first oncogenic hit, and results in constitutive activation of the anti-apoptotic BCL2 protein.