SEARCH OUR PRODUCT CATALOG

As of August 11th, Empire is operating as an essential New York State business and has no production or shipping delays

BCL6 Break Apart FISH Probe

Our BCL6 break apart probe is designed to detect BCL6 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs. 

Gene Background: B-Cell Lymphoma 6 (BCL6) encodes a zinc finger-type transcription factor that binds target DNA sequences to inhibit transcription by recruiting other repressor proteins to the binding site. BCL6 translocations are present in various lymphoma subsets, especially diffuse large B-cell lymphoma, where it’s the most frequent genetic abnormality, occurring in roughly 40% of cases. Rearrangements are also present in follicular lymphoma (5-10% of cases), Hodgkin lymphoma, and B-cell leukemia. The most common result of these rearrangements are fusion with IGH genes, accounting for about half of all known BCL6 translocations. However, the gene has also been shown to form fusions with an additional 30 partner genes.

Source: NIH.gov

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
BCL6BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
BCL6BA-20-GRGO 20 (40 μL) 200 μL
BCL6BA-20-GRRE 20 (40 μL) 200 μL
BCL6BA-20-GRAQ 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Gene Details

Gene Symbol: BCL6

Gene Name: B-cell CLL/lymphoma 6

Chromosome: CHR3: 187439164-187463513

Locus: 3q27.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.