BCL6 Break Apart FISH Probe
Our BCL6 break apart probe is designed to detect BCL6 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: B-Cell Lymphoma 6 (BCL6) encodes a zinc finger-type transcription factor that binds target DNA sequences to inhibit transcription by recruiting other repressor proteins to the binding site. BCL6 translocations are present in various lymphoma subsets, especially diffuse large B-cell lymphoma, where it’s the most frequent genetic abnormality, occurring in roughly 40% of cases. Rearrangements are also present in follicular lymphoma (5-10% of cases), Hodgkin lymphoma, and B-cell leukemia. The most common result of these rearrangements are fusion with IGH genes, accounting for about half of all known BCL6 translocations. However, the gene has also been shown to form fusions with an additional 30 partner genes.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|BCL6BA-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|BCL6BA-20-GRGO||20 (40 μL)||200 μL|
|BCL6BA-20-GRRE||20 (40 μL)||200 μL|
|BCL6BA-20-GRAQ||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|