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TFE3 & TFEB


Compared to adult renal cell carcinoma (RCC), pediatric and young adult RCC is fairly rare and poorly characterized. This team wanted to explore the genetic, molecular, and clinical spectrum of childhood and young adult RCC. They analyzed 68 RCC patients, all age 30 years or younger, using IHC and FISH. Our TFE3 and TFEB break apart FISH probes were used to detect rearrangements of the genes in cases that were morphologically suspicious for TFE3/TFEB translocations.

Published: 12/23/2019

Related Probes: TFE3 Break Apart Fish Probe


Renal cell carcinoma (RCC) can be subdivided into several categories based on morphology, histology, protein expression, and genetics. Although RCC can usually be classified using histological and immunohistochemical analysis, differential diagnosis can prove challenging in ambiguous cases. This study evaluated the efficacy of FISH in RCC classification via analysis of 539 RCC tumors. Empire Genomics’ TFEB break apart probes were used to detect TFEB translocations.

Published: 08/20/2019

Related Probes: TFEB Break Apart Fish Probe


Gastric Perivascular epithelioid cell tumor (PEComa) is an extremely rare tumor type - at the time of the study, only 7 cases had been reported so far. In this study, 2 new cases of PEComa were histologically and cytogenetically analyzed. In light of a recent study on a case of PEComa that harbored TFE3 fusion (and also exhibited unique features not typical of conventional PEComa), the tumors were screened for TFE3 rearrangements using Empire Genomics' TFE3 break-apart probe. Neither of the tumors were found to display TFE3 translocations.

Published: 05/29/2019

Related Probes: TFE3 Break Apart Fish Probe


Alveolar soft-part sarcoma (ASPS) is a rare malignant soft tissue tumor. The subject of this study was a 21 year old man who presented with ASPS of the prostate. Our ASPL and TFE3 break apart probes were used to confirm fusion of the two genes in the patient’s tumor, helping to elucidate the underlying genetic drivers of this extremely rare, aggressive neoplasm.

Published: 09/30/2018

Related Probes: TFE3 Fish Probe


Renal cell carcinomas with MITF family abnormalities display diverse morphologies. In order to better understand the association between MITF alterations and clinicopathologic characteristics, this team performed FISH analysis on 85 renal tumors using our TFE3 and TFEB break apart probes.

Published: 07/31/2017

Related Probes: TFE3 Break Apart Fish Probe