TFEB Break Apart FISH Probe

Empire Genomics’ TFEB Break Apart FISH Probe is designed to flank the TFEB gene and is typically used for detecting TFEB rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping

Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU	Test Kits	Buffer
TFEBBA-20-GROR (Standard Design)	20 (40 μL)	200 μL
TFEBBA-20-AQOR	20 (40 μL)	200 μL
TFEBBA-20-GOGR	20 (40 μL)	200 μL
TFEBBA-20-GORE	20 (40 μL)	200 μL
TFEBBA-20-GRGO	20 (40 μL)	200 μL
TFEBBA-20-GRRE	20 (40 μL)	200 μL
TFEBBA-20-ORGR	20 (40 μL)	200 μL
TFEBBA-20-REGO	20 (40 μL)	200 μL
TFEBBA-20-REGR	20 (40 μL)	200 μL

Gene Summary

The Transcription Factor EB (TFEB) gene is located on chr6:41651715 -41703997 at 6p21.1.

Gene Details

Gene Symbol: TFEB

Gene Name: Transcription Factor EB

Chromosome: CHR6: 41651715-41703997

Locus: 6p21.1

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Renal cell carcinomas with MITF family abnormalities display diverse morphologies. In order to better understand the association between MITF alterations and clinicopathologic characteristics, this team performed FISH analysis on 85 renal tumors using our TFE3 and TFEB break apart probes.

Histological and molecular characterization of TFEB-rearranged renal cell carcinomas

Renal cell carcinomas (RCCs) have historically been classified based on their morphology, anatomical location, or background renal disease. However, recurrent genetic abnormalities are being described more frequently in RCC, and have proven useful in the genetic classification of different RCC subsets. This study sought to clarify the underlying genetics of one such RCC subtype, TFEB-rearranged RCC. As part of genetic testing, Empire Genomics’ TFEB break apart probe was used to detect TFEB translocations in two RCC tumors, helping to verify the presence of a TFEB rearrangement in one case.

Diagnosis of uncommon renal epithelial neoplasms: performances of fluorescence in situ hybridization

Renal cell carcinoma (RCC) can be subdivided into several categories based on morphology, histology, protein expression, and genetics. Although RCC can usually be classified using histological and immunohistochemical analysis, differential diagnosis can prove challenging in ambiguous cases. This study evaluated the efficacy of FISH in RCC classification via analysis of 539 RCC tumors. Empire Genomics’ TFEB break apart probes were used to detect TFEB translocations.

Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature

Compared to adult renal cell carcinoma (RCC), pediatric and young adult RCC is fairly rare and poorly characterized. This team wanted to explore the genetic, molecular, and clinical spectrum of childhood and young adult RCC. They analyzed 68 RCC patients, all age 30 years or younger, using IHC and FISH. Our TFE3 and TFEB break apart FISH probes were used to detect rearrangements of the genes in cases that were morphologically suspicious for TFE3/TFEB translocations.

Product Details

Product: TFEB FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TFEB-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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