NTRK Gene Family

Our NTRK1 break apart probe was used to detect NTRK1 rearrangements in solid tumors from more than 1,000 patients. Over 14 different cancer types were analyzed, including lung, colorectal, and breast. NTRK1 translocations were identified in 5.9% of patients.

Published: 04/30/2018

Related Probes: NTRK1 Break Apart Fish Probe

Our NTRK1 break apart probe helped to detect a new NTRK1 fusion in a 61 year old patient with adenocarcinoma of the right colon and pancreas. The team was able to verify that this novel fusion – SCYL3-NTRK1 – was in fact an oncogenic driver by transfecting cells with a SCYL3-NTRK1 cDNA construct, which lead to IL3-independent proliferation.

Published: 07/24/2017

Related Probes: NTRK1 Break Apart Fish Probe

Our NTRK3 break apart probes were used to detect NTRK3 rearrangements in spitzoid neoplasms, a subtype of melanocytic tumors characterized by an absence of typical melanoma-associated mutations. Four of the patients tested positive for NTRK3 translocations, including a novel MYO5A-NTRK3 fusion.

Published: 05/01/2017

Related Probes: NTRK3 Break Apart Fish Probe

Atypical spitzoid neoplasms (APNs) are primarily pediatric lesions characterized by their intermediate features; clinically and histopathologically, they fall somewhere between benign spitz nevi and malignant melanoma. The genetics of these tumors are still poorly understood. In this study, 34 APNs were analyzed using FISH and IHC. Our ALK, BRAF, and NTRK1 break-apart FISH probes were used to detect rearrangements of the genes .

Published: 03/01/2017

Related Probes: NTRK1 Break Apart Fish Probe

Our ETV6-NTRK3 fusion probe was used to detect fusion of the two genes in a 36 year old patient with a neck tumor originally diagnosed as papillary thyroid carcinoma. After thyroid-targeted treatment proved unsuccessful, further cytogenetic analysis revealed the presence of a NTRK3-ETV6 fusion consistent with MASC’s clinical profile.

Published: 04/13/2016

Related Probes: ETV6-NTRK3 Fish Probe