NUP98/NSD1 Fusion FISH Probe

Our NUP98/NSD1 fusion probe is designed to detect fusions between NUP98 and NSD1. The probe comes labeled in orange and green, but can be customized to meet your needs. 

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NUP98-NSD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NUP98-NSD1-20-REGR 20 (40 μL) 200 μL

Gene Summary

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Gene Details

Gene Symbol: NUP98

Gene Name: Nucleoporin 98

Chromosome: CHR11: 3696239-3819022

Locus: 11p15.4

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Rapid detection of chromosomal translocation and precise breakpoint characterization in acute myeloid leukemia by nanopore long-read sequencing

Detection of chromosomal translocations has proven crucial for diagnosis and management of acute myeloid leukemia (AML), a cancer known to harbor several distinct gene rearrangements that correlate with disease subtype. In this study, an AML patient was genetically profiled using both conventional karyotyping and next generation sequencing techniques. FISH was also used to detect NUP98 translocations using Empire Genomics’ NUP98 break-apart probe.