ERG/TMPRSS2 Deletion/Break Apart FISH Probe
Our ERG/TMPRSS2 deletion/break apart probe is designed to detect the deletion between TMPRSS2 and ERG (which leads to TMPRSS2/ERG fusion), as well as translocations involving the TMPRSS2 region. The probe comes labeled in aqua, green, and orange, but can be customized to meet your needs.
Gene Background: TMPRSS2 is a prostate‑specific, androgen-response gene that encodes a serine protease. The gene has been shown to drive prostate carcinogenesis via fusion with ETS transcription factors, especially ERG and ETV1. ERG is an oncogene that encodes an erythroblast transformation‑specific transcription factor, a central monitor of cell proliferation, differentiation, angiogenesis, inflammation and apoptosis. TMPRSS2-ERG fusion is the most common genetic aberration in prostate cancer, occurring in > 50% of cases. The fusion results in overexpression of ERG, which isn’t normally expressed in prostate epithelia, and likely contributes to disease development by promoting tumor angiogenesis.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ERG-TMPRSS2-20-AQGROR (Standard Design)||20 (40 μL)||200 μL|
|ERG-TMPRSS2-20-AQGRGO||20 (40 μL)||200 μL|
|ERG-TMPRSS2-20-AQGRRE||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|