HLF/TCF3 Fusion FISH Probe
Our HLF/TCF fusion probe is designed to detect fusions between HLF and TCF3. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: HLF-TCF3 fusion produces a chimeric transcription factor that promotes apoptotic resistance during leukemic cell transformation.1 The fusion links the amino-terminal transactivation domains of TCF3 with the carboxy-terminal leucine zipper and basic domain of HLF, resulting in a hybrid protein with abnormal DNA binding affinity.1 HKF-TCF3 fusion is found in approximately 1% of acute lymphoblastic leukemia patients, where it's more frequent in children and young adults.2 Clinically, the abnormality is correlated with disseminated intravascular coagulation, hypercalcemia at diagnosis, and short survival.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLF-TCF3-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLF-TCF3-20-GRGO | 20 (40 μL) | 200 μL |
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| HLF-TCF3-20-GRRE | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLF
Gene Name: HLF, PAR BZIP Transcription Factor
Chromosome: CHR17: 53342320-53402426
Locus: 17q22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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