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RUNX1/MECOM Fusion FISH Probe

Our RUNX1/MECOM fusion probe is designed to detect fusions between RUNX1 and MECOM. The probe comes labeled in orange and green, but can be customized to meet your needs.

Gene Background: RUNX1-MECOM fusions generate a hybrid transcript made up of the runt homology domain of RUNX1 and the two zinc-finger clusters of MECOM.1 The fusion contributes to oncogenesis via dominant negative regulation of RUNX1 in transcriptional activation, apoptotic resistance (from the first zinc-finger domain), and increased cellular proliferation (from the second zinc-finger domain).1 RUNX1-MECOM is a rare but recurrent finding in therapy-related myeloid neoplasms, CML with accelerated or blastic phase, and de novo AML.2

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RUNX1-MECOM-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RUNX1-MECOM-20-REGR 20 (40 μL) 200 μL
RUNX1-MECOM-20-GOGR 20 (40 μL) 200 μL

Gene Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: RUNX1

Gene Name: Runt Related Transcription Factor 1

Chromosome: CHR21: 36160097-36421595

Locus: 21q22.12

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.