RUNX1/MECOM Fusion FISH Probe
Our RUNX1/MECOM fusion probe is designed to detect fusions between RUNX1 and MECOM. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: RUNX1-MECOM fusions generate a hybrid transcript made up of the runt homology domain of RUNX1 and the two zinc-finger clusters of MECOM.1 The fusion contributes to oncogenesis via dominant negative regulation of RUNX1 in transcriptional activation, apoptotic resistance (from the first zinc-finger domain), and increased cellular proliferation (from the second zinc-finger domain).1 RUNX1-MECOM is a rare but recurrent finding in therapy-related myeloid neoplasms, CML with accelerated or blastic phase, and de novo AML.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|RUNX1-MECOM-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
|RUNX1-MECOM-20-REGR||20 (40 μL)||200 μL|
|RUNX1-MECOM-20-GOGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|