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BCR/ABL1 Probe 10 Test

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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BCR-ABL1-10-ORGR  (Standard Design) 10 (20 μL) 100 μL

Gene Summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: BCR

Gene Name: BCR, RhoGEF And GTPase Activating Protein

Chromosome: CHR22: 23522551-23660224

Locus: 22q11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.