ERBB2 Probe 10 test
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB2-10-OR (Standard Design) | 10 (20 μL) | 100 μL |
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| ERBB2-10-RE | 10 (20 μL) | 100 μL |
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| ERBB2-10-AQ | 10 (20 μL) | 100 μL |
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| ERBB2-10-GR | 10 (20 μL) | 100 μL |
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| ERBB2-10-GO | 10 (20 μL) | 100 μL |
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Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ERBB2
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392-37884915
Locus: 17q12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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