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NTRK2 Break Apart FISH Probe

Empire Genomics' NTRK2 Break Apart FISH probe is designed to detect rearrangements of the NTRK2 gene at chromosomal region 9q21.33. The probe comes labeled in orange and green, but can be customized to meet your needs. A normal signal pattern will show two sets of overlapping orange and green signals. An abnormal pattern will show at least one set of split orange and green signals, indicating NTRK2 translocation.

Gene Background: NTRK2 is a receptor tyrosine kinase that binds brain-derived growth factor (BDGF) and neurotrophin 4/5 (NT-4/5) to phosphorylate itself and members of the MAPK pathway. The gene is essential to central and peripheral nervous system development and cell survival. NTRK2 rearrangements have been detected in several cancers, including glioblastoma, pilocytic astrocytoma, head and neck squamous cell carcinoma, and lung adenocarcinoma. These rearrangements generate fusion genes encoding hybrid proteins composed of the TK domain of NTRK2 and the N-terminus of the partner protein, which always contains a dimerization domain. The chimeric proteins displays ligand-independent TK activity, leading to unchecked cell proliferation and tumorigenesis.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

Turnaround Time: 7-10 Business Days

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SKU Test Kits Buffer Dye Color Order Now
NTRK2BA-20-ORGR  (Standard Design) 20 (40μL) 200 μL
NTRK2BA-20-GOGR 20 (40μL) 200 μL
NTRK2BA-20-GRGO 20 (40μL) 200 μL
NTRK2BA-20-REGR 20 (40μL) 200 μL
NTRK2BA-20-REGO 20 (40μL) 200 μL