NTRK2 Break Apart FISH Probe
Our NTRK2 Break Apart Probe is designed to detect NTRK translocations. The probe comes labeled in orange and green but can be customized to meet your needs.
Gene Background: NTRK2 is a receptor tyrosine kinase that binds brain-derived growth factor (BDGF) and neurotrophin 4/5 (NT-4/5). The gene is essential to central and peripheral nervous system development and cell survival. NTRK2 rearrangements have been detected in many cancers, including glioblastoma, pilocytic astrocytoma, head and neck squamous cell carcinoma, and lung adenocarcinoma. These rearrangements generate fusion genes encoding hybrid proteins with ligand-independent TK activity, leading to unchecked cell proliferation and tumorigenesis.
Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NTRK2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NTRK2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| NTRK2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| NTRK2BA-20-REGR | 20 (40 μL) | 200 μL |
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| NTRK2BA-20-REGO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: NTRK2
Gene Name: Neurotrophic Receptor Tyrosine Kinase 2
Chromosome: CHR9: 87283465-87638505
Locus: 9q21.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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