Our RB1/LAMP1 probe is designed to detect RB1 and LAMP1 amplifications and deletions. The probe comes labeled in orange and green, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Symbol: RB1
Gene Name: RB Transcriptional Corepressor 1
Chromosome: CHR13: 48877882-49056026
FISH Probe Protocols
|Protocol, Procedure, or Form Name
Renal oncocytoma (RO) is a benign epithelial neoplasm that makes up about 5 to 9% of all renal cell tumors. RO can be difficult to distinguish from a closely related but malignant counterpart, chromophobe renal cell carcinoma (ChrCC). This study used both IHC and FISH to detect the presence of RB1 and ERBB4, two genes that have been found deleted in ChrCC but not RO. A total of 28 ChrCCs and 25 RO cases were tested. Empire Genomics’ RB1 and ERBB4 FISH probes were used to detect deletions in these genes.