ATM/TP53 FISH Probe
Our ATM/TP53 FISH probe is designed to detect ATM and TP53 deletions. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: Chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world, is characterized by a heterogeneous genetic profile, including aberrations in TP53 and ATM.1 TP53, a well-established tumor suppressor, is mutated in about 15% of CLL patients.2 ATM encodes a kinase that’s been shown to activate TP53’s encoded protein via two mechanisms: phosphorylation of the protein at serine 15 and dephosphorylation at serine 376.3 Therefore, ATM loss is a potential cause of TP53 dysfunction in CLL. Reduced levels of ATM’s encoded protein are found in 30-40% of CLL patients.2 Beyond CLL, TP53 abnormalities have also been detected in a number of hematological malignancies, including acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndromes, while ATM has been found deregulated in pediatric leukemias, lymphomas, and breast cancers.3,4
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ATM-TP53-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|ATM-TP53-20-GRRE||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|