MAML2 Break Apart FISH Probe

Our MAML2 Break Apart Probe is designed to detect MAML2 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.

Probe Detail:

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MAML2BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MAML2BA-20-GRRE 20 (40 μL) 200 μL
MAML2BA-20-GOGR 20 (40 μL) 200 μL
MAML2BA-20-GRGO 20 (40 μL) 200 μL
MAML2BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]

Gene Details

Gene Symbol: MAML2

Gene Name: Mastermind Like Transcriptional Coactivator 2

Chromosome: CHR11: 95711439-96076344

Locus: 11q21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.