ROS1 Break Apart Extended FISH Probe

Empire Genomics' ROS1 Break Apart extended probe to detect a translocations of the ROS1 gene at chromosomal region 6q221.1. Extended break apart probes have longer probe lengths than their standard break apart counterparts. This is intended to amplify signal intensity, making the probes easier to visualize under the microscope. The probe comes labeled in green and orange, but can be cusomized to meet your needs. 

Gene Background: The ROS1 gene codes for the ROS1 tyrosine kinase insulin receptor, a type I integral membrane protein that binds cell growth and differentiation signaling factors.¹ Rearrangements of ROS1 have been implicated in a multitude of cancers, including NSCLC, gastric cancer, ovarian cancer, colorectal cancer, and various epithelial malignancies.² These translocations produce fusion proteins, constitutively activating the kinase domain of ROS1.³

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

• Product Details
• Gene Details
• Protocols
• Customer Publications (1)

SKU	Test Kits	Buffer	Dye Color	Order Now
ROS1BA-EXT-20-GROR  (Standard Design)	20 (40 μL)	200 μL		View Pricing

Gene Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: ROS1

Gene Name: ROS Proto-oncogene 1, Receptor Tyrosine Kinase

Chromosome: CHR6: 117609529-117747018

Locus: 6q22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Comprehensive Genomic Profiling of Malignant Effusions in Patients with Metastatic Lung Adenocarcinoma

In this study, the utility of performing targeted next-generation sequencing (NGS) on malignant effusions from patients with metastatic lung adenocarcinoma was investigated. NGS is a high throughput technology, which utilizes a small sample input, but the suitability of NGS analysis for tissue-free cytology samples such as malignant body fluids is not well understood. In order to investigate the adequacy of NGS on liquid biopsies of MLA, targeted NGS was performed using custom target panels consisting of many oncogenes. Additional non-NGS molecular tests were performed on the effusion samples, including fluorescence in situ hybridization (FISH) analysis for the oncogene ROS1, using a break-apart FISH probe manufactured by Empire Genomics.

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