NTRK3 Break Apart FISH Probe

Our NTRK3 Break Apart probe is designed to detect NTRK3 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: NTRK3 encodes the TrkC receptor, a glycoprotein expressed in the human hippocampus, cerebral cortex and in the granular cell layer of the cerebellum. NTRK3 rearrangements have been detected in a variety of malignancies, including glioblastoma, fibrosarcoma, thyroid cancer, and acute myeloid leukemia. Many of these translocations result in fusion with ETV6; the resulting fusion gene, which differs in its breakpoints depending on the cancer type, has been shown to be an oncogenic driver in its associated diseases.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

Available as CE marked product in certain countries

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NTRK3BA-20-GOGR 20 (40 μL) 200 μL
NTRK3BA-20-ORGR 20 (40 μL) 200 μL
NTRK3BA-20-REGO 20 (40 μL) 200 μL
NTRK3BA-20-GRRE 20 (40 μL) 200 μL
NTRK3BA-20-REGR 20 (40 μL) 200 μL
NTRK3BA-20-REAQ 20 (40 μL) 200 μL
NTRK3BA-20-GROR 20 (40 μL) 200 μL
NTRK3BA-20-GRGO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Gene Details

Gene Symbol: NTRK3

Gene Name: Neurotrophic Receptor Tyrosine Kinase 3

Chromosome: CHR15: 88419987-88799962

Locus: 15q25.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms

Our NTRK3 break apart probes were used to detect NTRK3 rearrangements in spitzoid neoplasms, a subtype of melanocytic tumors characterized by an absence of typical melanoma-associated mutations. Four of the patients tested positive for NTRK3 translocations, including a novel MYO5A-NTRK3 fusion.