BCR/ABL1 Fusion FISH Probe
Our BCR/ABL1 fusion probe is designed to detect fusions between BCR and ABL1. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: The BCR-ABL1 fusion gene, also known as the Philadelphia Chromosome, was the first genetic abnormality to be considered a biomarker for a specific cancer.1 First identified in 1960 in chronic myeloid leukemia cells, the fusion is formed via a reciprocal translation between the Abelson (ABL1) gene and the Breakpoint Cluster Region (BCR) gene.1 The fusion encodes a constitutively activated tyrosine kinase protein, which causes abnormal cell proliferation, angiogenesis, metastasis, and deregulated apoptotic response in cells, all which contribute to leukemia development.2 BCR-ABL1 is found in virtually all cases of chronic myeloid leukemia (CML), and is also the most common cytogenetic aberration in adults with acute lymphoblastic leukemia (ALL), occurring in roughly 25% of cases.3 Prevalence rises with age; approximately 50% of ALL patients over the age of 50 harbor the fusion, but it’s only found in 5% of pediatric patients.4
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|BCR-ABL1-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|BCR-ABL1-20-ORGR||20 (40 μL)||200 μL|
|BCR-ABL1-20-GRRE||20 (40 μL)||200 μL|
|BCR-ABL1-20-REGR||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|