DEK/NUP214 (CAN) FISH Probe
Our DEK/NUP214 fusion probe is designed to detect fusions between DEK and NUP214. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: The t(6;9)(p22;q34) chromosomal translocation is found in 1-2% of pediatric acute myeloid leukemia (AML) cases. First described in 1976, the rearrangement produces a DEK/NUP214 fusion protein comprising almost all of DEK alongside the carboxy-terminal two thirds of NUP214. The fusion typically occurs in de novo AML, where it’s found as the sole karyotypic abnormality in 80% of cases. Of the 20% of patients with accompanying secondary abnormalities, gains in chromosome 8 and 13 are the most common.
Source: Sandahl JD, et al. (2014) Haematologica. 99.5: 865-872.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|DEK-NUP214-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|DEK-NUP214-20-GRRE||20 (40 μL)||200 μL|
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Symbol: DEK
Gene Name: DEK Proto-oncogene
Chromosome: CHR6: 18224399-18264799
FISH Probe Protocols
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