TP53 FISH Probe
Our TP53 FISH probe is designed to detect TP53 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
Gene Background: The tumor protein 53 gene encodes a transcription factor which regulates cell proliferation, differentiation, and apoptosis, and functions as a tumor suppressor by activating the expression of genes that inhibit cell growth.1 TP53 is the most frequently mutated gene in human cancer; it's abnormally expressed in 50% of cancer patients.2 TP53 mutations have been detected in 16% of acute lymphocytic leukemias, 12% of acute myeloid leukemias, 7% of chronic lymphocytic leukemias, 6% of myelodyplastic syndromes, and are also very common in a variety of solid tumors.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TP53-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| TP53-20-BIO | 20 (40 μL) | 200 μL |
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| TP53-20-RE | 20 (40 μL) | 200 μL |
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| TP53-20-AQ | 20 (40 μL) | 200 μL |
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| TP53-20-DIG | 20 (40 μL) | 200 μL |
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| TP53-20-GR | 20 (40 μL) | 200 μL |
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| TP53-20-GO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Gene Details
Gene Symbol: TP53
Gene Name: Tumor Protein P53
Chromosome: CHR17: 7571719-7590863
Locus: 17p13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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