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TOP2A FISH Probe

Our TOP2A probe is designed to detect TOP2A amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs. 

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TOP2A-20-OR  (Standard Design) 20 (40 μL) 200 μL
TOP2A-20-RE 20 (40 μL) 200 μL
TOP2A-20-AQ 20 (40 μL) 200 μL
TOP2A-20-GR 20 (40 μL) 200 μL
TOP2A-20-GO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Gene Details

Gene Symbol: TOP2A

Gene Name: DNA Topoisomerase II Alpha

Chromosome: CHR17: 38544772-38574202

Locus: 17q21.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.