TOP2A FISH Probe
Our TOP2A probe is designed to detect TOP2A amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOP2A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOP2A-20-RE | 20 (40 μL) | 200 μL |
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| TOP2A-20-AQ | 20 (40 μL) | 200 μL |
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| TOP2A-20-GR | 20 (40 μL) | 200 μL |
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| TOP2A-20-GO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Gene Details
Gene Symbol: TOP2A
Gene Name: DNA Topoisomerase II Alpha
Chromosome: CHR17: 38544772-38574202
Locus: 17q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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