RUNX1T1-RUNX1 Fusion FISH Probe
Our RUNX1T1/RUNX1 fusion probe is designed to detect fusions between RUNX1T1 and RUNX1. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: Acute myeloid leukemia (AML) harboring RUNX1T1-RUNX1 fusion is now a WHO-recognized AML subset.1 The fusion is found in approximately 5-12% of AML patients, and is more common in children and young adults.2 The t(8;21) breakpoint usually occurs in the intron between exons 5 and 6, just before the transactivation domain.2 The generated fusion protein is made up of the DNA-binding domain of RUNX1 fused to the transcription factor RUNX1T1, and is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RUNX1T1-RUNX1-20-REGR | 20 (40 μL) | 200 μL |
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| RUNX1T1-RUNX1-20-ORGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Details
Gene Symbol: RUNX1T1
Gene Name: RUNX1 Translocation Partner 1
Chromosome: CHR8: 92967194-93115454
Locus: 8q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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