ROS1 Break Apart FISH Probe
Our ROS1 Break Apart Probe is designed to detect ROS1 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: The ROS1 gene codes for the ROS1 tyrosine kinase insulin receptor, a type I integral membrane protein that binds cell growth and differentiation signaling factors.1 Rearrangements of ROS1 have been implicated in a multitude of cancers, including NSCLC, gastric cancer, ovarian cancer, colorectal cancer, and various epithelial malignancies.2 These translocations produce fusion proteins, constitutively activating the kinase domain of ROS1.3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ROS1BA-20-GROR (Standard Design)||20 (40 μL)||200 μL|
|ROS1BA-20-GRGO||20 (40 μL)||200 μL|
|ROS1BA-20-GRRE||20 (40 μL)||200 μL|
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Gene Symbol: ROS1
Gene Name: ROS Proto-oncogene 1, Receptor Tyrosine Kinase
Chromosome: CHR6: 117609529-117747018
FISH Probe Protocols
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