MYB Break Apart FISH Probe
Our MYB break apart probe is designed to detect MYB translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: MYB encodes a transcription factor that is highly expressed in immature, proliferating epithelial, endothelial, and hematopoietic cells. The gene has been found to be amplified in pancreatic, colon, and breast tumors. MYB is also highly expressed in most human myeloid leukemias and acute lymphocytic leukemias, suggesting that it may play a more general role in leukemogenesis, potentially acting as an essential cofactor for other oncogenes in the induction and maintenance of these leukemias. MYB’s contribution to leukemogenesis includes promoting proliferation and suppressing apoptosis, frequently via translocation of the gene to a fellow transcription factor that promotes MYB overactivation.
Source: Zhao L, et al. Oncogene (2014) 33.35: 4442.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYBBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYBBA-20-GRGO | 20 (40 μL) | 200 μL |
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| MYBBA-20-GRRE | 20 (40 μL) | 200 μL |
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| MYBBA-20-GRAQ | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: MYB
Gene Name: MYB Proto-oncogene, Transcription Factor
Chromosome: CHR6: 135502452-135540311
Locus: 6q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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