MLL Break Apart FISH Probe
Our MLL break apart FISH probe is designed to detect MLL translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: MLL encodes a histone lysine N-methyltransferase. The MLL protein contributes to multiple cellular processes, including hematopoiesis, DNA damage response, and cell cycle control. MLL rearrangements have been detected in 5-6% of acute myeloid leukemias (AML) and 5-10% of acute lymphoblastic leukemias (ALL). These translocations are significantly more frequent in infants with AML (50%) and ALL (80%). The most common MLL rearrangements are t(4;11) and t(11;19) in ALL, and t(6;11), t(9;11), and t(11;19) in AML, and more than 30 MLL fusion partners have been identified so far.
Sources:
Broeker PL, et al. (1996) Blood 87: 1912-22.
De Braekeleer M, et al. (2005) Anticancer Res 25: 1931-44.
Ford DJ & Dingwall AK (2015) Cancer Genet 208: 178-91.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MLLBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| MLLBA-20-GRRE | 20 (40 μL) | 200 μL |
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FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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