MECOM Tri-Color Break Apart FISH Probe
Our MECOM tri-color break apart probe is designed to detect MECOM translocations. The probe comes labeled in orange, green, and aqua, but can be customized to meet your needs.
Gene Background: MECOM (MDS1 and EVI1 complex locus) encodes a zinc finger protein that acts as a transcriptional regulator.1 Abnormal MECOM expression usually results from its rearrangement, the most common being inv(3)(q21;q26.2) and t(3;21)(q36.2;q22).2 The breakpoints for these abnormalities differ considerably.3 The gene is frequently mutated in hematological malignancies of myeloid origin, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).2 AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) is a WHO-recognized disease entity, characterized by aberrations involving MECOM at 3q26.2 and RPN1 (ribophorin I) at 3q21.2 MECOM has also been found rearranged in therapy-related disease via t(3;21)(q26.2;q22), resulting in fusion with RUNX1.3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MECOMBA-20-AQGROR (Standard Design) | 20 (40 μL) | 200 μL |
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| MECOMBA-20-AQGRRE | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Details
Gene Symbol: MECOM
Gene Name: MDS1 And EVI1 Complex Locus
Chromosome: CHR3: 168801286-169381563
Locus: 3q26.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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