JAK2 Break Apart FISH Probe
Our JAK2 break apart probe is designed to detect JAK2 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: JAK2 encodes a tyrosine kinase that directs progression of the JAK2/STAT signaling cascade, a pathway crucial to hematopoeisis and immune cell development.1 JAK2 translocations have been detected in a variety of myeloproliferative diseases and hematopoietic tumors.2 These rearrangements usually transfer JAK2’s 39 kinase domain to a fusion partner, resulting in constitutive activation of JAK2.3 These fusions are recurrent in myeloproliferative neoplasms (MPN), acute myeloid leukemia, acute lymphoblastic leukemia and lymphoma.2 Three fusion variants in MPN, namely PCM1-JAK2, BCR-JAK2 and ETV6-JAK2, are thought to be constitutively activated drivers of the disease process analogous to BCR-ABL1 in chronic myeloid leukemia.4
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JAK2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JAK2BA-20-REGR | 20 (40 μL) | 200 μL |
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| JAK2BA-20-GOGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: JAK2
Gene Name: Janus Kinase 2
Chromosome: CHR9: 4985244-5128183
Locus: 9p24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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