FGFR1 Break Apart FISH Probe

Our FGFR break apart probe is designed to detect FGFR1 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: FGFR1 translocations are hallmarks of 8p11 myeloproliferative syndrome (EMS), also known as stem cell leukemia/lymphoma syndrome, an aggressive stem cell myeloproliferative neoplasm associated with eosinophilia, T-cell lymphoma, and frequent progression to acute myeloid leukemia.1 T(8;13)(p11.2;q12.1) is the most common rearrangement in EMS, resulting in fusion of FGFR1 to ZMYM2 (a.k.a. ZNF198).2 Other FGFR1 rearrangements are also prevalent in EMS, and all generate fusion proteins composed of the tyrosine kinase domain of FGFR1 and a dimerization domain of a partner protein, leading to constitutively activated kinase activity.3

FGFR1 Break Apart FISH Probe Ideogram

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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SKU Test Kits Buffer Dye Color Order Now
FGFR1BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FGFR1BA-20-REGR 20 (40 μL) 200 μL
FGFR1BA-20-GROR 20 (40 μL) 200 μL
FGFR1BA-20-GRGO 20 (40 μL) 200 μL
FGFR1BA-20-GOGR 20 (40 μL) 200 μL
FGFR1BA-20-GRRE 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: FGFR1

Gene Name: Fibroblast Growth Factor Receptor 1

Chromosome: CHR8: 38268655-38326352

Locus: 8p11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.