FGFR1 Break Apart FISH Probe
Our FGFR break apart probe is designed to detect FGFR1 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: FGFR1 translocations are hallmarks of 8p11 myeloproliferative syndrome (EMS), also known as stem cell leukemia/lymphoma syndrome, an aggressive stem cell myeloproliferative neoplasm associated with eosinophilia, T-cell lymphoma, and frequent progression to acute myeloid leukemia.1 T(8;13)(p11.2;q12.1) is the most common rearrangement in EMS, resulting in fusion of FGFR1 to ZMYM2 (a.k.a. ZNF198).2 Other FGFR1 rearrangements are also prevalent in EMS, and all generate fusion proteins composed of the tyrosine kinase domain of FGFR1 and a dimerization domain of a partner protein, leading to constitutively activated kinase activity.3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|FGFR1BA-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
|FGFR1BA-20-REGR||20 (40 μL)||200 μL|
|FGFR1BA-20-GROR||20 (40 μL)||200 μL|
|FGFR1BA-20-GRGO||20 (40 μL)||200 μL|
|FGFR1BA-20-GOGR||20 (40 μL)||200 μL|
|FGFR1BA-20-GRRE||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|