ETV6 Break Apart FISH Probe
Our ETV6 break apart probe is designed to detect ETV6 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: ETV6 encodes a DNA-binding protein involved in transcriptional regulation during embryonic development and hematopoiesis.1 The gene is altered in 2.82% of all cancers with leukemia, myelodysplastic syndromes, non-small cell lung carcinoma, breast carcinoma, and colorectal adenocarcinoma having the highest frequency of alterations.1 So far, more than 40 ETV6 rearrangements and 30 fusion partners have been identified in a multitude of hematological and non-hematological malignancies.2,3
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ETV6BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ETV6BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ETV6BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ETV6BA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ETV6BA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ETV6BA-20-GRRE | 20 (40 μL) | 200 μL |
|
Gene Summary
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Gene Details
Gene Symbol: ETV6
Gene Name: ETS Variant 6
Chromosome: CHR12: 11802787-12048325
Locus: 12p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|