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CCND1-IGH Full FISH Probe

Our CCND1/IGH full fusion probe is designed to detect fusions between CCND1 and IGH. This full probe, unlike our split CCND1/IGH probe, covers the entire IGH gene. It comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: CCND1/IGH fusion is generated by t(11;14)(q13.3;q32.3), which places CCND1 next to IGH, resulting in constitutive overexpression of CCND1. The fusion can be found in up to 95% of patients with mantle cell lymphomas (MCL), and is considered the genetic hallmark of this subtype of low-grade peripheral B-cell neoplasms. CCND1/IGH fusion has also been identified in other lymphoproliferative disorders (LPDs), such as B-prolymphocytic leukemia (BLL), and, less frequently, in plasma cell myelomas and B-cell chronic lymphocytic leukemia (CLL).

Source: Bentz JS, et al. (2004) Cancer 102:124-31. 

*The region in which the IGH gene lies is known for high levels of cross-homology with other genomic regions, which can lead to diffuse probe signals.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CCND1-IGH-Full-20-ORGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CCND1

Gene Name: Cyclin D1

Chromosome: CHR11: 69455872-69469242

Locus: 11q13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.