CCND1-IGH Full FISH Probe
Our CCND1/IGH full fusion probe is designed to detect fusions between CCND1 and IGH. This full probe, unlike our split CCND1/IGH probe, covers the entire IGH gene. It comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: CCND1/IGH fusion is generated by t(11;14)(q13.3;q32.3), which places CCND1 next to IGH, resulting in constitutive overexpression of CCND1. The fusion can be found in up to 95% of patients with mantle cell lymphomas (MCL), and is considered the genetic hallmark of this subtype of low-grade peripheral B-cell neoplasms. CCND1/IGH fusion has also been identified in other lymphoproliferative disorders (LPDs), such as B-prolymphocytic leukemia (BLL), and, less frequently, in plasma cell myelomas and B-cell chronic lymphocytic leukemia (CLL).
*The region in which the IGH gene lies is known for high levels of cross-homology with other genomic regions, which can lead to diffuse probe signals.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|CCND1-IGH-Full-20-ORGR||20 (40 μL)||200 μL|
FISH Probe Protocols
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