BCL2 Break Apart FISH Probe
Our BCL2 break apart probe is designed to detect BCL2 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: The B-Cell Lymphoma 2 gene (BCL2) encodes an apoptosis inhibitor protein, and was the first anti-death gene ever discovered. Deregulated BCL2 results in blockages to programmed cell death, extending cell survival to promote abnormal tissue growth. BCL2 translocations are a genetic hallmark of B-Cell lymphomas, especially follicular lymphoma (FL). In FL, BCL2 rearranges to the IGH locus, resulting in the constitutive activation of BCL2. The gene has also been found to drive the development of many other cancers, including skin, breast, prostate, colorectal and lung cancer, as well as a host of psychiatric and autoimmune diseases.
Source: Campbell K, et al. (2018) Open biology 8.5:180002.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCL2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCL2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: BCL2
Gene Name: BCL2, Apoptosis Regulator
Chromosome: CHR18: 60790578-60986613
Locus: 18q21.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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