ALK Break Apart FISH Probe
Our ALK break apart probe is designed to detect ALK translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: ALK encodes a tyrosine kinase receptor which plays a crucial role in intracellular signal transduction, allowing for cell growth and differentiation.1 Aberrations in ALK, especially translocations, have been found to play a significant role in the development of over 20 different types of cancers, especially lung and lymph.2 Approximately 3-5% of non-small cell lung cancer (NSCLC) cases harbor ALK translocations.3 These rearrangments most frequently occur via fusion of the 3’-portion of ALK, encoding its oncogenic kinase domain, with the 5’-portion of a partner gene, putting ALK under control of the partner’s promoter.2 ALK’s most frequent fusion partner in NSCLC is EML4, but over 30 different fusion genes have been identified, albeit in lower frequencies than EML4, in tumors of ALK-associated cancers.4 NSCLC patients with ALK translocations are typically younger women with no smoking history, and the most frequent tumor pathological type is adenocarcinoma.4
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ALKBA-20-ORGR (Standard Design)||20 (40 μL)||200 μL|
FISH Probe Protocols
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