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ABL1 Break Apart FISH Probe

Empire Genomics' ABL1 Break Apart FISH probe is designed to detect rearrangements of the ABL1 gene at chromosomal region 9q34.11-q34.13. The probe comes labeled in green and orange, but can be customized to meet your needs. A normal signal pattern will show two sets of overlapping orange and green signals. An abnormal pattern while show at least one set of split orange and green signals, indicating ABL1 translocation.

Gene Background: The ABL1 protein regulates actin binding and remodeling, cell motility and adhesion, receptor endocytosis and autophagy. It also aids in checkpoint repair after moderate DNA damage, and apoptosis after serious damage. Best known for its fusion with BCR in chronic myeloid leukemia, which produces the well-known BCR-ABL1 fusion gene or Philadelphia Chromosome, ABL1 has also been shown to fuse with several other partner genes. These include ETV6 in ALL, MPN, and Ph-negative CML; RCSD1, SEPQ, and ZMIZ1 in B-cell ALL; and NUP214 and EML1 in T-cell ALL. All of these fusions result from the joining of the 5’ sequences of the partner gene with the 3’ sequences of ABL1. Although most ABL1 fusion genes are associated with a distinct leukemia subtype, both BCR-ABL1 and ETV6-ABL1 are found in several disease phenotypes. Some studies have suggested that these non-specific fusion occur in hematopoietic pluripotent or committed stem cells, leading to leukemia with diverse phenotypes.

Source: De Braekeleer E, et al. (2011) Euro jour haem 86.5: 361-371.

SKU Test Kits Buffer Dye Color Order Now
ABL1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
ABL1BA-20-GRGO 20 (40 μL) 200 μL
ABL1BA-20-GRRE 20 (40 μL) 200 μL