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YAP1 FISH Probe

The YAP1 FISH probe is designed to hybridize to the YAP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
YAP1-20-OR  (Standard Design) 20 (40 μL) 200 μL
YAP1-20-RE 20 (40 μL) 200 μL
YAP1-20-GO 20 (40 μL) 200 μL
YAP1-20-GR 20 (40 μL) 200 μL
YAP1-20-AQ 20 (40 μL) 200 μL
YAP1-20-DIG 20 (40 μL) 200 μL
YAP1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

Gene Details

Gene Symbol: YAP1

Gene Name: Yes Associated Protein 1

Chromosome: CHR11: 101981191-102104154

Locus: 11q22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging

Ependymoma is a tumor of the central nervous system that can exhibit fusion of the RELA gene. Diagnosing these accurately is important, and can be done with FISH, IHC, or DNA methylation. FISH analysis was performed with RELA break apart probes (RP11_58D3 and RP11_436C17/RP11_1104L6). MN1 and YAP1 break apart probes were also used in conjunction with the DNA methylation.
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Childhood supratentorial ependymomas with YAP1_MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features

Ependymoma is a tumor that arises from tissue of the nervous system. Rare cases involve a YAP1/MAMLD1 fusion that can occur in childhood. This study sought to expand on the unique clinical features of neoplasms harboring this fusion. Our YAP1 break apart probe was used to detect YAP1 gene rearrangements in several of the cases under study. It was determined that YAP1/MAMLD1 fusion ependymomas display characteristics that distinct from RELA fusion ependymomas.
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Product Details

Product: YAP1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: YAP1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping