WRNIP1 Break Apart FISH Probe
Empire Genomics’ WRNIP1 Break Apart FISH Probe is designed to flank the WRNIP1 gene and is typically used for detecting WRNIP1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WRNIP1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-GORE | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-GROR | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-REGO | 20 (40 μL) | 200 μL |
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| WRNIP1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Gene Details
Gene Symbol: WRNIP1
Gene Name: Werner Helicase Interacting Protein 1
Chromosome: CHR6: 2765665-2785979
Locus: 6p25.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: WRNIP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: WRNIP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping