WRNIP1 FISH Probe
The WRNIP1 FISH probe is designed to hybridize to the WRNIP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| WRNIP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-RE | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-GO | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-GR | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| WRNIP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Gene Details
Gene Symbol: WRNIP1
Gene Name: Werner Helicase Interacting Protein 1
Chromosome: CHR6: 2765665-2785979
Locus: 6p25.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: WRNIP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: WRNIP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping