VHLL FISH Probe
The VHLL FISH probe is designed to hybridize to the VHLL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| VHLL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| VHLL-20-RE | 20 (40 μL) | 200 μL |  |
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| VHLL-20-GO | 20 (40 μL) | 200 μL |  |
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| VHLL-20-GR | 20 (40 μL) | 200 μL |  |
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| VHLL-20-AQ | 20 (40 μL) | 200 μL |  |
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| VHLL-20-DIG | 20 (40 μL) | 200 μL |  |
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| VHLL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]
Gene Details
Gene Symbol: VHLL
Gene Name: VHL Like
Chromosome: CHR1: 156268414-156269428
Locus: 1q22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: VHLL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: VHLL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping