USP6 FISH Probe

Benign spindle cell lesions of the breast are a rare and varied subset of lesions that can be difficult to distinguish from other tumor types. This study presented three different cases of benign spindle cell lesions - solitary fibrous tumor (SFT), nodular pseudoangiomatous stromal hyperplasia (PASH) and nodular fasciitis (NF) - and highlighted the different histological and cytogenetic techniques that could be used to identify them. Empire Genomics’ USP6 break-apart probe was used to test breast tissue biopsies for rearrangements in the USP6 gene, which has been found to occur in more than 90% of NF cases. Researchers recommended using FISH to help diagnose future cases where NF is suspected but can’t be solely determined through morphological or immunohistochemical means.