UPF3B FISH Probe
The UPF3B FISH probe is designed to hybridize to the UPF3B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UPF3B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-RE | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-GO | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-GR | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-AQ | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-DIG | 20 (40 μL) | 200 μL |  |
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| UPF3B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: UPF3B
Gene Name: UPF3B, Regulator Of Nonsense Mediated MRNA Decay
Chromosome: CHRX: 118967988-118986991
Locus: Xq24
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: UPF3B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: UPF3B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping