UPF3A Break Apart FISH Probe
Empire Genomics’ UPF3A Break Apart FISH Probe is designed to flank the UPF3A gene and is typically used for detecting UPF3A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UPF3ABA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-AQOR | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-GOGR | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-GORE | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-GRGO | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-GROR | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-GRRE | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-REGO | 20 (40 μL) | 200 μL |
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| UPF3ABA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Details
Gene Symbol: UPF3A
Gene Name: UPF3A, Regulator Of Nonsense Mediated MRNA Decay
Chromosome: CHR13: 115047058-115071291
Locus: 13q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: UPF3A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: UPF3A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping