UHRF1 FISH Probe
The UHRF1 FISH probe is designed to hybridize to the UHRF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UHRF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-RE | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-GO | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-GR | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| UHRF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Gene Details
Gene Symbol: UHRF1
Gene Name: Ubiquitin Like With PHD And Ring Finger Domains 1
Chromosome: CHR19: 4909509-4962165
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: UHRF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: UHRF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping