TYROBP FISH Probe
The TYROBP FISH probe is designed to hybridize to the TYROBP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TYROBP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-RE | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-GO | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-GR | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-AQ | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-DIG | 20 (40 μL) | 200 μL |  |
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| TYROBP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Gene Details
Gene Symbol: TYROBP
Gene Name: TYRO Protein Tyrosine Kinase Binding Protein
Chromosome: CHR19: 36395302-36399211
Locus: 19q13.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TYROBP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TYROBP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping