SEARCH OUR PRODUCT CATALOG

TXNRD3 Break Apart FISH Probe

Empire Genomics’ TXNRD3 Break Apart FISH Probe is designed to flank the TXNRD3 gene and is typically used for detecting TXNRD3 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TXNRD3BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
TXNRD3BA-20-AQOR 20 (40 μL) 200 μL
TXNRD3BA-20-GOGR 20 (40 μL) 200 μL
TXNRD3BA-20-GORE 20 (40 μL) 200 μL
TXNRD3BA-20-GRGO 20 (40 μL) 200 μL
TXNRD3BA-20-GRRE 20 (40 μL) 200 μL
TXNRD3BA-20-ORGR 20 (40 μL) 200 μL
TXNRD3BA-20-REGO 20 (40 μL) 200 μL
TXNRD3BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]

Gene Details

Gene Symbol: TXNRD3

Gene Name: Thioredoxin Reductase 3

Chromosome: CHR3: 126325894-126373967

Locus: 3q21.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: TXNRD3 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TXNRD3-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping