TXNRD3 FISH Probe
The TXNRD3 FISH probe is designed to hybridize to the TXNRD3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TXNRD3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-RE | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-GO | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-GR | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-AQ | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-DIG | 20 (40 μL) | 200 μL |  |
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| TXNRD3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: TXNRD3
Gene Name: Thioredoxin Reductase 3
Chromosome: CHR3: 126325894-126373967
Locus: 3q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TXNRD3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TXNRD3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping