TTN Break Apart FISH Probe
Empire Genomics’ TTN Break Apart FISH Probe is designed to flank the TTN gene and is typically used for detecting TTN rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTNBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTNBA-20-AQOR | 20 (40 μL) | 200 μL |
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| TTNBA-20-GOGR | 20 (40 μL) | 200 μL |
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| TTNBA-20-GORE | 20 (40 μL) | 200 μL |
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| TTNBA-20-GRGO | 20 (40 μL) | 200 μL |
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| TTNBA-20-GRRE | 20 (40 μL) | 200 μL |
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| TTNBA-20-ORGR | 20 (40 μL) | 200 μL |
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| TTNBA-20-REGO | 20 (40 μL) | 200 μL |
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| TTNBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Gene Details
Gene Symbol: TTN
Gene Name: Titin
Chromosome: CHR2: 179390717-179672150
Locus: 2q31.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TTN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TTN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping